Department of Pharmacy, Islamic Azad University, Damghan Branch, Damghan, Iran
Research Article
Alpha-Lipoic Acid Decreases Pain, Anxiety-Like Behaviors and Oxidative Stress in the Periaquadactal Gray Matter in Methamphetamine-Treated Rats
Author(s): Hossain Mohammadpour Kargar* and Yousof Mousavi
Objective: Methamphetamine (Met) is a highly addictive psychostimulant that elevates the amount of dopamine in the brain. Dopamine accumulation leads to oxidative stress and eventually induces brain damage. Alpha-Lipoic Acid (ALA) is a potent natural antioxidant in the body, and reduction of oxidative stress by ALA has been shown in animal models. In this study, we investigated the effects of intraperitoneal administration of alpha-lipoic acid on anxiety-like behaviors, pain perception, and oxidative stress in the periaqueductal gray in Met-induced neurotoxicity.
Methods: Thirty-five male Wistar rats were divided into five equal groups: 1) saline+saline, 2) saline+vehicle (sunflower oil as ALA solvent), 3) Met+vehicle, 4) Met+ALA (10 mg/kg), and 5) Met+ALA (40 mg/kg). Rats received methamphetamine repeatedly (2 × 20 mg/kg, 2 hour inter.. View More»
DOI:
10.35248/NCOA.24.10(1).104
