The use of mTOR inhibitor for the treatment of refractory seizure | 49439

Journal of Neuroscience and Neuropharmacology

The use of mTOR inhibitor for the treatment of refractory seizures in an infant with hemimegencephaly

7th Global Experts Meeting on NEUROPHARMACOLOGY

July 31-August 02, 2017 | Milan, Italy

Anita N Datta, Qi Xu, Shimrit Uliel-Sibony, Cyrus Boelman, Christopher Dunham, Mary B Connolly and Harvey Sarnat

University of British Columbia, Canada

Scientific Tracks Abstracts: Neurochem Neuropharm

Abstract :

Hemimegalencephaly (HME) is a hamartomatous malformation involving one cerebral hemisphere, often resulting in treatment resistant seizures, intellectual disability, and autistic features. Hemispherectomy is the definitive treatment, but there is risk of high morbidity and mortality, especially when done in early infancy. Various preclinical studies have shown that dysregulation of the mTOR pathway has an integral role in the development of various epilepsy syndromes, including tuberous sclerosis complex (TSC), focal cortical dysplasia and HME. Recently, mTOR inhibitors were proven to effective in treating seizures in TSC. We present a case of a patient, who presented at 6 days of age with treatment resistant epilepsy, despite the trial of 9 anti-seizure medications and the ketogenic diet. As the patient was awaiting epilepsy surgery, an mTOR inhibitor, rapamycin was initiated. After 1 week of the initiation, she had more than 50% reduction in seizure frequency and total seizure burden and the duration of seizures decreased. (Total seizure burden was calculated as the total amount of time occupied by electrographic seizures during the video-EEG monitoring.) At two weeks, the parents felt that for the first time, she was making developmental gains. She also appeared brighter and more interactive. Due to her response to treatment, her hemispherectomy was deferred to when she was older with an increased weight. She had a functional hemispherectomy without any complications and is now seizure free. This case exemplifies how mTOR inhibitors should be considered as a treatment option for patients with HME and refractory epilepsy.

Biography :

Anita N Datta is a Clinical Assistant Professor in Pediatrics at the University of British Columbia. She is a Fellow of the Royal College of Physicians and Surgeons of Canada, and is Board Certified by the American Board of Psychiatry and Neurology Child Neurology and Clinical Neurophysiology. She obtained her MD from the University of Saskatchewan, and completed Pediatric Neurology residency at the University of Alberta. She completed an Epilepsy and Clinical Neurophysiology fellowship at Boston Children’s Hospital. She is a National Examiner for the Canadian Society of Clinical Neurophysiology. She is currently a Program Director of the Epilepsy fellowship training program. Her primary clinical interest is epilepsy and its surgical management. She is also involved in the Tuberous Sclerosis Clinic and is part of the Ketogenic Diet team. Her research interests include clinical epilepsy, neurophysiology and neuropsychological outcomes. She has authored peer reviewed publications and book chapters in these areas.