Mi Young Lee
Korea Institute of Oriental Medicine, Republic of Korea
Posters & Accepted Abstracts: Neurochem Neuropharm
Stress is closely linked to various diseases. The excessive stress can lead to alterations in the brain activity, immune system, mitochondria system, neuroendocrine system, and sympathetic nervous system, via activation of the hypothalamuspituitary- adrenal (HPA) axis. In this study, corticosterone-treated SK-N-SH cells displayed decreased cell viability, ATP levels, and MMPs compared to untreated SK-N-SH cells. HSF ex and HSR ex may play an important role in ameliorating the correlation between stress and the development of depression. HSF ex and HSR ex are able to prevent CORT-induced neuronal cell death via activation of the BDNF signaling pathway.
Mi Young Lee has completed her PhD from Konkuk University of Korea. She works on Standardization and Development of Medicinal Herbs more than 20 years. Currently, she is the Project Manager for the Study on the Anti-depression Effect of Korea Traditional Medicine. She has published more than 50 papers in reputed journals.