Neuroprotective effects of medicinal herb extract on corticostero | 48840

Journal of Neuroscience and Neuropharmacology

Neuroprotective effects of medicinal herb extract on corticosterone-induced neurotoxicity, (neuro) inflammation, mitochondrial function and expression of BDNF

4th Global Experts Meeting on Neuropharmacology

September 14-16, 2016 San Antonio, USA

Mi Young Lee

Korea Institute of Oriental Medicine, Republic of Korea

Posters & Accepted Abstracts: Neurochem Neuropharm

Abstract :

Stress is closely linked to various diseases. The excessive stress can lead to alterations in the brain activity, immune system, mitochondria system, neuroendocrine system, and sympathetic nervous system, via activation of the hypothalamuspituitary- adrenal (HPA) axis. In this study, corticosterone-treated SK-N-SH cells displayed decreased cell viability, ATP levels, and MMPs compared to untreated SK-N-SH cells. HSF ex and HSR ex may play an important role in ameliorating the correlation between stress and the development of depression. HSF ex and HSR ex are able to prevent CORT-induced neuronal cell death via activation of the BDNF signaling pathway.

Biography :

Mi Young Lee has completed her PhD from Konkuk University of Korea. She works on Standardization and Development of Medicinal Herbs more than 20 years. Currently, she is the Project Manager for the Study on the Anti-depression Effect of Korea Traditional Medicine. She has published more than 50 papers in reputed journals.