Dissociable functions of the ACC and OFC: From lesion studies to | 48863

Journal of Neuroscience and Neuropharmacology

Dissociable functions of the ACC and OFC: From lesion studies to pharmacology

4th Global Experts Meeting on Neuropharmacology

September 14-16, 2016 San Antonio, USA

Abbas Khani

University of Fribourg, Switzerland

Posters & Accepted Abstracts: Neurochem Neuropharm

Abstract :

The functional dissociation of the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC) during decision making have been a major focus of research recently. These dissociations have been revealed in several dimensions of decision making including cost processing and dependence on stimulus-guided or action-guided functions. While these dissociations have usually been studied using lesion studies, we have extended such dissociable functions to pharmacological manipulations and showed that cannabinoid system activation in the ACC and OFC results in dissociable disruption of costbenefit decision making. Putting together the relevant lesion and neuroimaging studies in both human and animal species together with single neuron and pharmacological manipulations, I will discuss the similarities and differences in the role of the ACC and OFC with a special emphasis on pharmacology of functional dissociations between these two key brain regions.

Biography :