Saeed Mohammadi
Islamic Azad University, Iran
Posters & Accepted Abstracts: Neurochem Neuropharm
Statement of the Problem: Tanacetum balsamita is one of the important medicinal plants that are used by Iranian folk medicines. This study aimed to assess the phytochemical Screening, analgesic and anti-inflammatory effects of Tanacetum balsamita essential oil in rats. Methodology & Theoretical Orientation: The essential oil of Tanacetum balsamita (EOTB) was treatment in doses of 10, 50, and 100 mg/kg. In addition, antinociceptive activity of EOTB was evaluated by formalin, writhing, and tail-flick tests. The EOTB was also combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene induced ear edema. Moreover, the EOTB origin has been analyzed by a combination of GC and GC/MS. Rotarod test was used for evaluation effect of EOTB on motor coordination. Findings: The EOTB at doses of 10-100 mg/kg have been shown significant analgesic effects (p<0.05). In compare of morphine and indomethacin, use of naloxone plus EOTB has been inhibited pain in all three models. The present results showed anti-inflammatory effect of EOTB in the xylene induced ear edema test in compare to dexamethasone. Quercetin as a main constituent of EOTB has been significantly decreased pain (p<0.001). In the rotarod test EOTB did not significantly impair the motor performance. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EOTB on the formalin test, suggesting the involvement of K ATP channels and muscarinic receptors. The major components in the tested oils were mainly contained quercetin, isoquercitrin and luteolin. Conclusion & Significance: Findings propose that EOTB probably have analgesic and anti-inflammatory effects. Existent of quercetin may be an important reason for mentioned effects.
Email: smiauhphd.sm@gmail.com
