Editorial office, Journal of Neuroscience and Neuropharmacology, Brussels, Belgium
Perspective
Current Understanding of Neurodevelopmental Diseases Linked to SLC6A1
Author(s): Dennis Zhang*
monogenic cause of neurodevelopmental diseases such as epilepsy with myoclonic atonic seizures, autism spectrum disorder, and intellectual impairment thanks to advances in gene identification. The principal inhibitory neurotransmitter in the central nervous system, GABA, is reabsorbed from the extracellular space by the GABA transporter protein type 1 that is encoded by the solute carrier family 6 member 1 gene. In order to balance neuronal excitement, GABAergic inhibition is crucial, and when it is considerably disturbed, seizures and developmental abnormalities result. Understanding of the genotypic and phenotypic range of this condition is expanded by the collection of patient variations and documented clinical symptoms. We evaluate genetics here. & behavioral traits in 116 people who have solute carrier family 6 members 1 mutation; the great majority of these polymorphisms are.. View More»
DOI:
10.4172/2469-9780.2022.8.4.179
