Journal of Neuroscience and Neuropharmacology

Adacolumn Therapeutic

Adacolumn selectively adsorbes granulocytes, monocytes/macrofages with the help of Fcγ and complement receptors. Approximately 65% of granulocytes and 55% of monocytes from the blood that passes through the column, are adsorbed. However the count of blood cells will not go down below the healthy level as the entrapped activated cells are rapidly replaced by mobilisation of inactive, CD-10 negative leukocytes. This means that apheresis with Adacolumn has rather a qualitative than quantitative effect, i.e. activated leukocytes are replaced by inactive cells. Additionally, Adacolumn leukocyte adsorption is associated with sustained down-modulation of pro-inflammatory cytokines like TNF-u, IL-1v, IL-6 and IL-8 released by blood leukocytes together with downmodulation of L-selectin and the chemokine receptor CXCR3 which mediate migration of leukocytes from blood into the inflammatory tissue.The blood passes through the Adacolumn where activated granulocytes and monocytes/macrophages are removed and the blood returns to the patient via a venopuncture in the opposite arm. The extracorporeal flow rate is 30 ml/min and the duration of one treatment session is 60 min. A small dose of heparin is used as an anticoagulant

Relevant Topics in Neuroscience & Psychology