Hamed R Takruri and Baha�a M Abu Salama
The University of Jordan, Jordan
Posters & Accepted Abstracts: Primary Health Care
The pregnant women are exposed to atherogenic state during pregnancy characterized by hypertriglyceridemia. Omega-3 LCPUFAs are proposed to have a lipid lowering effect during pregnancy. The aim of this study was to explore the possible influence of maternal omega-3 LCPUFAs supplementation during the last trimester of pregnancy on serum lipid concentrations. In this randomized intervention study, a total of 84 pregnant women at their 20 weeks of gestation were enrolled and divided into two groups: Group1 (n=42) women who received 600 mg omega-3 LCPUFAs daily (containing 550 mg DHA and 50 mg EPA) the end of supplementation. Women who received supplementation during pregnancy had significantly lower plasma concentration of triglycerides (-65.12 mg/dl, p=0.001) and higher HDL-C (13.69 mg/dl, p=0.001) than the control group. Maternal plasma concentration of triglycerides was independently and inversely associated with the level of omega-3 index in maternal plasma (�²=-12.65 mg/dl, p=0.004), and positively associated with the ratio of omega-6: omega-3 fatty acids (�²= 5.51 mg/dl, p=0.004) after adjusting for confounders. It is concluded that omega-3 fatty acids supplementation would improve the blood lipid profile in pregnant women through thypotriglyceridemic effect and increase HDL-C concentration which in turn reduce the incidence of atherogenesis.
Email: htakruri@ju.edu.jo
