National Medical Research Center for Children's Orthopedics and Trauma Surgery, Saint-Petersburg, Russian Federation
Steroid intra-articular injections in children with oligoarticular onset juvenile arthritis: 7-years follow-up study.
Author(s): Kozhevnikov A.N*, Pozdeeva N.A, Nikitin M.S, Bogdanova S.L and Novik G.A
Introduction: Intra-articular steroid injections are the first-line antirheumatic drugs of oligoarticular onset juvenile arthritis (oligo-JA). Despite significant advances in treatment (anti-TNF, block IL6) the choice of DMARDs for the pediatric chronic joint disease remains relevant. This study aimed to search for candidate biomarkers influencing efficacy treatment by early intra-articular steroid injections in children with oligo-JA. Patients and Methods: Efficacy of early isolated intra-articular injections of triamcinolone acetonide was analyzed in 120 children with oligoarticular onset Juvenile Arthritis (JA). Results and Discussion: 42 children (all girls; 35%) were achieved remission JA after one or two isolated intra-articular injections (is- IAI) of Triamcinolone Acetonide (TA). 78 children (54% girls; 11%.. View More»