Department of Pharmacology and Clinical Toxicology, Istituto di Biofisica, CNR, Via de Marini, Genova, Italy
Research Article
Investigating the Microrheological Properties of Knee Synovial Fluid by Means of the Multiple Tracking Technique
Author(s): Alessandra Ludovico, Oscar Moran and Debora Baroni*
Osteoarthritis, the most common joint disease worldwide, refers to a heterogeneous group of conditions that share symptoms and signs of compromised articular cartilage integrity and alterations in bone and joint margins. The pathophysiology of osteoarthritis is not comprehensively understood and its treatment is mainly symptomatic. Intra-articular injections of corticosteroids and hyaluronic acid-based preparations are commonly employed to mitigate pain and enhance joint function by replenishing damaged synovial fluid. This study aimed to evaluate the microrheological properties of the synovial fluid under conditions that mimic in vitro the healthy and the oxidized condition, which characterizes the synovial fluid in osteoarthritic subjects. Additionally, the microviscosity properties of the synovial fluid were evaluated after administration of two pharmaceutical agents for t.. View More»
DOI:
10.35248/2167-7921.24.13(1).105
