Background: This study was conducted to determine the effects of vitamin C supplementation with and without endurance physical activity on calcium and parathyroid hormone levels in metabolic syndrome patients.
Methods: In a parallel-randomized, double-blind, placebo-controlled clinical trial, 120 metabolic syndrome patients, was randomly assigned into four groups. Biochemical tests were assessed as baseline and after 12 weeks of intervention. Statistical analysis was performed using SPSS version 20.
Findings: A significant decrease in mean serum calcium levels were seen in participants who received vitamin C or “vitamin C plus 30 minutes/day of physical activity” and “placebo plus 30 minutes/day of physical activity” (p value<0.001). Furthermore, we observed a significant decrease in mean serum levels of parathyroid hormone in participants who received vitamin C or “vitamin C plus 30 minutes/ day of physical activity” compared with other two groups (p value<0.001). Also, taking vitamin C plus 30 minutes/day of physical activity, lowered parathyroid hormone more in compared with only taking vitamin C (- 5.77 ± 7.29 vs. - 4.98 ± 9.54).
Conclusions: We conclude that, adding physical activity to vitamin C supplement might be particularly important in regulation of parathyroid hormone and serum calcium levels in metabolic syndrome patients.