Human pluripotent
stem cells (hPSCs), i.e. human
embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into multiple cell types. Because of these abilities, numerous attempts have been made to utilize hPSCs in regenerative medicine/cell therapy. hPSCs are, however, also tumorigenic, that is, they can give rise to the progressive growth of
tumor nodules in immunologically unresponsive animals. Therefore, assessing and managing the
tumorigenicity of all final products is essential in order to prevent ectopic tissue formation,
tumor development, and/or malignant transformation elicited by residual pluripotent
stem cells after implantation. No detailed guideline for the
tumorigenicity testing of hPSC-derived products has yet been issued for regenerative medicine/cell therapy, despite the urgent necessity. Here, we describe the current situations and issues related to the
tumorigenicity testing of hPSC-derived products and we review the advantages and disadvantages of several types of tumorigenicity-associated tests. We also refer to important considerations in the execution and design of specific studies to monitor the
tumorigenicity of hPSC-derived products. Human Pluripotent
Stem Cell (PSC)-derived cell therapy holds enormous promise because of the cells’ “unlimited” proliferative capacity and the potential to differentiate into any type of cell. However, these features of PSC-derived cell products are associated with concerns regarding the generation of iatrogenic teratomas or tumors from residual immature or non-terminally differentiated
cells in the final cell product. This concern has become a major hurdle to the introduction of this therapy into the clinic.
Tumorigenicity testing is therefore a key preclinical safety test in PSC-derived cell therapy. Citations are important for a journal to get impact factor. Impact
factor is a measure reflecting the average number of citations to recent
articles published in the journal. The impact of the journal is influenced by impact factor, the
journals with high impact
factor are considered more important than those with lower ones. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research
articles but also review
articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports.
Relevant Topics in Neuroscience & Psychology