Medicinal chemistry and pharmaceutical chemistry are disciplines of pharmacy at the intersection of chemistry, especially synthetic organic chemistry, and
pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodies, hormones, etc.). Inorganic and organometallic compounds are also useful as
drugs (e.g., lithium and platinum-based agents such as lithium carbonate and cisplatin as well as gallium). In particular,
medicinal chemistry in its most common practice—focusing on small organic molecules—encompasses synthetic
organic chemistry and aspects of natural products and
computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing
drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity
relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products. At the biological interface,
medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as biochemistry, molecular biology, pharmacognosy and pharmacology,
toxicology and veterinary and human medicine; these, with project management, statistics, and pharmaceutical
business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in treatment of disease.
High Impact List of Articles
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Prevalence and Associated Factors of Cigarette Smoking
among Type 2 Diabetes Patients in Pakistan
Naila Khalid, Ejaz Ahmad Khan , Shifa Saleem , Adeel Tahir , Hassan Mahmood , Sarah Saleem
: International Journal of Collaborative Research on Internal Medicine & Public Health
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Continuous Quality Improvement: Adherence to
Performance Measures - Implementation of Antiplatelet,
Statin, Beta-Blocker and Angiotensin System Blockade
Therapy Post Myocardial Infarction, Compliance with
ACC/AHA Guidelines
Sachin Kumar Amruthlal Jain , Timothy R Larsen , Mohammad
Nasser , I. Sam Tandon , Shukri David : International Journal of Collaborative Research on Internal Medicine & Public Health
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The Stem Cell Debate
Tehseen Fatima Ali1 , Dr. Tabinda Hasan, Dr. A. R. Siddiqui : International Journal of Collaborative Research on Internal Medicine & Public Health
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A G15719C Leptin Gene Polymorphism is Associated with
Lesser Perception of Stress and Other Physiological Reactions to Stress in Adult Working Pakistani Women
Zeba Haque, Farzana Yasmeen, Darakhshan J Haleem : International Journal of Collaborative Research on Internal Medicine & Public Health
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The Length of Cigarette Smoking is the Principal Risk Factor
for Developing COPD
Senaida Bianovi : International Journal of Collaborative Research on Internal Medicine & Public Health
Relevant Topics in Medical Sciences
