Neurology and Neurorehabilitation

Shahar Shelly

Shahar Shelly, MD
Assistant Professor, Neurology, Mayo Clinic
Mayo Clinic Rochester, USA


His early career has focused on utilizing big data to provide clinical disease insights and disease biomarkers. This was especially possible in the Mayo Clinic environment where I spent 3.5 years. Using big data extraction tools, it is possible to inform diagnosis even prior to major clinical symptomatology. These same tools may inform not only for early diagnosis but also early treatment response in various immune modulating therapies and possibly gene knock down and replacement therapies in the future. In my research career I completed a research fellowship at Mayo Clinic Rochester MN with the Neuroimmunology department and described a new antigen that is now tested in clinical practice (Neurochondrin DOI: 10.1212/NXI.0000000000000612) and conducted basic electrophysiological research on patients with Lambert Eaton myasthenic syndrome. I have also introduced insights on existing newly described antigen (neural intermediate filaments). I have completed 2 more clinical years of muscle and nerve disease fellowship in which I have also published on myasthenia gravis, immune check point inhibitors myopathy, desmin related myopathy as well as necrotizing immune myopathy, small fiber neuropathy and inclusion body myositis in 5 separated manuscripts. All these studies are longitudinal epidemiological outcome studies within depth pathological and clinical concepts.

Research Interest

Big data, Artificial Intelligence, Translational discovery of biomarkers in neurology.