Department of Trauma Sequelae and Rheumatoid Arthritis, Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
Research Article
Serum Calprotectin like a Potential Serum Biomarker of Aggressive Erosive Course of Juvenile Arthritis
Author(s): Kozhevnikov AN*, Pozdeeva NA, Maricheva ON, Murashko TV, Bogdanova SL, Derkach EA, Vissarionov SV and Novik GA
Introduction: Juvenile Arthritis (JA) is an autoimmune inflammatory joint disease. There is no reliable laboratory test for JA. Some researchers reported that the serum levels of calprotectin may be correlated with arthritis activity.
Materials and methods: Level of serum Calprotectin (sCal) was evaluated in 70 children with JIA (50 active JIA/20 inactive arthritis) and 20 adolescents with non-rheumatic joint disease. In comparison the serum level of IL6, TNF-alpha, and vimentin were assessed.
Results: Statistical analysis were revealed a correlation between sCalc and active erosive JA (R2=0.4159, T=4.336, OR erosive JA=3.3193, 95%CI 1,7006-6.4789, p=0.0079). Serum level of vimentin, IL6 and TNF-alpha were not always correlated with active stage JA and erosive joint damage (p>0,05). The ROC analysis o.. View More»
DOI:
10.4172/2167-7921.2022.11.058