Editorial Office, Journal of Health and Medical Research, Belgium
Perspective
Higher Sensitivity to the Anti-Metabolic Agent Shikonin and Enhanced Bioenergetics of Ovarian Cancer Cells are Associated with Upregulation of Succinate Dehydrogenase (SDHA)
Author(s): Olivier Morel Morel*
We found that the highly metabolically active phenotype is promoted by the overexpression of the mitochondrial enzyme Succinate Dehydrogenase (SDHA), which is particularly common in ovarian cancer. Prior research has examined succinate dehydrogenase insufficiency in a few uncommon diseases. There is still a need for more study because it has never been done how SDHA overexpression affects ovarian cancer metabolism. We looked into the effects of SDHA overexpression in ovarian cancer on its functional properties. We investigated the protein content of the metabolic pathways, cell proliferation, anchorage-independent growth, mitochondrial respiration, glycolytic activity, and ATP production rates in those cells using proteomics techniques and biological experiments. Last but not least, we ran a pharmacological screening to find medicines that selectively target tumor cells that overexpre.. View More»
