Shandong Qianfo Mountain Hospital, Jinan, Shandong, China
Review Article
AQP4 Participates in Cognitive Regulation in Alzheimer's Disease
Author(s): Mengzhen Zhou and JiyouTang*
Background: It is believed that the main pathological changes in Alzheimer's disease are abnormal deposition of β-amyloid (Aβ) protein and phosphorylation of tau in the brain, and various in vitro and in vivo experiments have shown that aquaporin 4 (AQP 4) may be responsible for Aβ metabolism and clearance in Alzheimer's disease.
Objective: To provide a new direction for the diagnosis and treatment of Alzheimer's disease by characterizing the structure and function of AQP 4 and the function and possible mechanism of AQP 4 in the clearance of Aβ in Alzheimer's disease.
Conclusion: Strengthening of the regulatory effect of Aqp 4 on lymphatic function in the brain has an important effect on the development, progression and outcome of Alzheimer's disease. Aqp 4 agonists or agents.. View More»
DOI:
10.35248/2332-2594.23.14 (6).341
