Department of Neurology, Research Laboratory LR12SP01, Charles Nicolle Hospital, Tunis, Tunisia
A Case Report of Central Nervous System Demyelinaion in a Patient with Rheumatoid Arthritis: Is it Multiple Sclerosis?
Author(s): Ichrak Ghachem, Saloua Fray, Héla Jamoussi, Meriem Ben Mahmoud, Nadia Ben Ali and Mohamed Fredj*
Background: Patients with rheumatoid arthritis (RA) may have central nerve system (CNS) comorbidities such us demyelinating lesions. In current practice, this clinical situation raises an etiological problem of this demyelination; is it linked to treatments; anti TNF drugs, which is the most frequent case? or is it a primary demyelination of the CNS?. Case report: We reported the case of a 52-year-old woman followed for seronegative Rheumatoid arthritis (RA) treated with methotrexate that presented clinical and radiological multifocal inflammatory demyelinating lesions. No etiology related to RA or its treatment could explain the radioclinical presentation of the patient. Magnetic resonance imaging lesions fulfilling MC Donald’s criteria for Multiple Sclerosis (MS) and analysis of cerebrospinal fluid showed intrathecal synthesis of oligoc.. View More»