Journal of Multiple Sclerosis

ISSN - 2376-0389
NLM - 101654564

George H Kraft

Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA, USA


  • Research Article   
    A Clinical Perspective: Somatosensory Evoked Potentials May Suggest MS Type and Care Management
    Author(s): George H Kraft, Katie T Singsank*, Sarah B Simmons and James D Bowen

    Background: This Multiple Sclerosis (MS) is a Central Nervous System (CNS) disease characterized by demyelination or axonal loss encompassing several clinical subtypes—Relapsing-Remitting MS (RRMS), Secondary-Progressive MS (SPMS), and Primary-Progressive MS (PPMS). Strategies for treating progressive forms are limited, and better understanding of underlying pathophysiology is essential. Method: Somatosensory Evoked Potentials (SEP) were analyzed for CNS conduction slowing caused by myelin impairment defined as 3 or more standard deviations, in 109 people with MS (16 with PPMS compared to 93 with RRMS and/or SPMS). Results: People with RRMS and SPMS have a higher prevalence of CNS conduction slowing compared to PPMS (83.9% compared to 12.5% respectively, P<.001). Subgroup analysis suggests this is not due .. View More»
    DOI: 10.35248/2376-0389.21.8.241

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