Editorial Office, Journal of Health and Medical Research, Belgium
Opinion
During Hepatocarcinogenesis, DNA Methylation Regulates a Set of Long Non-Coding RNAs that Compromise Hepatic Identity
Author(s): Derek Jones*
Hepatocarcinogenesis is a long-term process that results in hepatic function decline. Our goal is to learn more about the processes involved in this disease process so that we may help create novel diagnostic markers and treatment targets. We discovered a group of Long non-coding RNAs (lncRNAs) that are highly downregulated in Hepatocellular Carcinoma (HCC) and are associated with the grade of tumour dedifferentiation and patients' poor prognosis in this study. Our findings suggest that they are linked to hepatic differentiation, and that at least a subset of those lncRNAs is necessary for the expression of other hepato-specific genes required for liver function. Furthermore, we show that DNA methylation silences the expression of these lncRNAs in HCC. Overall, we discover linked epigenetic changes that are implicated in the progression of liver cancer and identify potential new b.. View More»
DOI:
10.37532/jhmr.2022. 4(3).115
