International Journal of Collaborative Research on Internal Medicine & Public Health

ISSN - 1840-4529

Alessandro Luigi

Editorial Office, International Journal of Collaborative Research on Internal Medicine and Public Health, Italy


  • Review   
    Inflammatory Bowel Diseases and the Vitamin D Axis: Role, Current Uses, and Future Prospects
    Author(s): Alessandro Luigi*

    The idea that the vitamin D axis has immunoregulatory functions is gaining traction, with vitamin D receptor (VDR) status being the most important determinant of vitamin D's pleiotropic effects. Vitamin D stimulates the formation of antimicrobial peptides such as -defensins and cathelicidins, as well as autophagy and epithelial barrier integrity, as well as the shift toward Th2 immune responses. Vitamin D deficiency has been linked to a variety of chronic inflammatory disorders, including inflammatory bowel disease (IBD). Inhibition of vitamin D pathways causes dysbiosis of the gut microbiome, which has been linked to the development of IBD in a molecular approach. The significance of the vitamin D axis in immune-mediated disorders is examined in this paper, with a focus on its interaction with the gut microbiome in the pathogenesis of IBD... View More»
    DOI: 10.35248/1840-4529.22.14.341

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