Violeta Vlad
Romania
Research Article
How Useful is Anti-TNF Serum Level and Anti-drug Antibodies Detection in Evaluating Patients with Spondyloarthritis?
Author(s): Claudia Oana Deaconu, Daniela Opris, Diana Mazilu, Andreea Borangiu, Laura Groseanu, Ioana Saulescu, Cecilia Gainaru, Magdalena Negru, Cosmin Constantinescu, Violeta Bojinca, Violeta Vlad, Andra Balanescu, Denisa Predeteanu and Ruxandra IonescuClaudia Oana Deaconu, Daniela Opris, Diana Mazilu, Andreea Borangiu, Laura Groseanu, Ioana Saulescu, Cecilia Gainaru, Magdalena Negru, Cosmin Constantinescu, Violeta Bojinca, Violeta Vlad, Andra Balanescu, Denisa Predeteanu and Ruxandra Ionescu
Objective: The aim of this study was to assess whether infliximab and adalimumab drug serum levels and the detection of anti-drug antibodies can be of use in better observing disease activity in patients with spondyloarthritis, besides classical tools such as BASDAI, ASDAS and inflammatory markers. We proposed to evaluate the influence of ADA in non-responders and in drug-related adverse events.
Methods: Over one year, we enrolled 115 patients with SpA, treated with infliximab or adalimumab. Patients who delayed prescribed drug administration were excluded from the study cohort. The population comprised 69 patients - 33 on IFX and 35 on ADA. NSAIDs administration was recommended “on demand”. Demographic, clinical (BASDAI, ASDAS) and laboratory (ESR, CRP) data was collected together with drug serum level and anti-drug antibodies usi.. View More»
