Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Toru Yamashita and Koji Abe

Toru Yamashita and Koji Abe
Department of Neurology, Okayama University Graduate School of Medicine, Okayama,

  • Review Article
    Endogenous Neurogenesis, Oligodendrogenesis and Angiogenesis after Ischemic Brain Injury
    Author(s): Toru Yamashita and Koji AbeToru Yamashita and Koji Abe

    Since strokes are a major cause of death and result in a drastic reduction in the quality of life, a new strategy to minimize ischemic-related damage is thus required. Recent evidence indicates that endogenous neural stem cells of the subventricular zone give rise to not only neurons but also oligodendrocytes, which can restore a disrupted neuronal network in post-ischemic brain, and various kinds of neurotrophic factors, such as EGF, are known to promote this process. To promote the functional recovery of post-stroke brain, angiogenesis is also essential. It has been suggested that circulating endothelial progenitor cells (EPCs) can play an important role in angiogenesis of the post-stroke brain. The number or function of EPCs can also be modulated by various kinds of factors. For example, VEGF, G-CSF and statins can increase EPC levels. In this review, we discuss the present knowled.. Read More»
    DOI: 10.4172/2155-9562.S8-003

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