Journal of Multiple Sclerosis

ISSN - 2376-0389
NLM - 101654564

Thomas H. Bak

Thomas H. Bak

United Kingdom

  • Research Article
    Impairment of Visual Cognition in Progressive Multiple Sclerosis

    Author(s): Thomas H. Bak, Siddharthan Chandran and Peter ConnickThomas H. Bak, Siddharthan Chandran and Peter Connick

    Background: Impairment of visual cognition occurs in up to 25% of patients with MS, however data on progressive disease is limited and the neural basis remains unknown. Objective: To evaluate the influence of multifocal inflammatory CNS white matter demyelination burden on visual cognition in equivalent SPMS and PPMS cohorts. Methods: 59 SPMS and 27 PPMS patients matched for demographic and disease characteristics were evaluated using visuospatial and visuoperceptual components of the Addenbrooke’s cognitive examination-revised (ACE-R) battery. Factors influencing performance were then identified by logistic regression. Exploratory logistic models were also used to determine the predictive value of deficits in attention, working memory, and arithmetic abilities. Finally, comparison of deficits between equivalent .. View More»


Relevant Topics