Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Peter Connick
University of Edinburgh Centre for Clinical Brain Sciences,
Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB
United Kingdom
Research Article
Impairment of Visual Cognition in Progressive Multiple Sclerosis
Author(s): Thomas H. Bak, Siddharthan Chandran and Peter ConnickThomas H. Bak, Siddharthan Chandran and Peter Connick
Background: Impairment of visual cognition occurs in up to 25% of patients with MS, however data on progressive disease is limited and the neural basis remains unknown.
Objective: To evaluate the influence of multifocal inflammatory CNS white matter demyelination burden on visual cognition in equivalent SPMS and PPMS cohorts.
Methods: 59 SPMS and 27 PPMS patients matched for demographic and disease characteristics were evaluated using visuospatial and visuoperceptual components of the Addenbrooke’s cognitive examination-revised (ACE-R) battery. Factors influencing performance were then identified by logistic regression. Exploratory logistic models were also used to determine the predictive value of deficits in attention, working memory, and arithmetic abilities. Finally, comparison of deficits between equivalent .. View More»
