Monaco A
Italy
Research Article
Mitochondrial Genome Profile in Demyelinating Diseases
Author(s): Durastanti V, Monaco A, Caronti B, Cortese A, Fustaino V, Wang E, Berardelli A, Marincola FM and Millefiorini EDurastanti V, Monaco A, Caronti B, Cortese A, Fustaino V, Wang E, Berardelli A, Marincola FM and Millefiorini E
Multiple sclerosis and neuromyelitis optica are chronic inflammatory diseases of the central nervous system.
These pathologies share clinical similarities with Leber hereditary optic neuropathy, which is primarily due to mutations
of mitochondrial DNA. Mitochondrial genetic variations may influence susceptibility to develop multiple sclerosis and
neuromyelitis optica. In order to explore the possible correlation between mitochondrial DNA specific patterns and
demyelinating diseases involving central nervous system, mitochondrial DNA from 13 patients with relapsing-remitting
multiple sclerosis, 4 patients with neuromyelitis optica, 1 patient with myelitis, 2 patient with optic neuritis, and 7
healthy controls were analyzed by sequencing the full length 16 Kbs of the mitochondrial DNA genome. Common
variants presence in healthy controls a.. View More»
