Matthew Sorenson
Associate Professor/Associate Director DePaul University School of Nursing,
990 West Fullerton Ave., Suite 3000, Chicago, IL. 60614
Tanzania
Research Article
Brain Derived Neurotrophic Factor is Decreased in Chronic Fatigue Syndrome and Multiple Sclerosis
Author(s): Matthew Sorenson, Leonard Jason, Jonna Peterson, Joshua Herrington and Herbert MathewsMatthew Sorenson, Leonard Jason, Jonna Peterson, Joshua Herrington and Herbert Mathews
Objective:
This study examined the levels of a major regulator of neuronal survival, brain derived neurotrophic factor (BDNF) in two populations: individuals with multiple sclerosis and chronic fatigue syndrome. BDNF is a protein involved in the maintenance and maturation of both peripheral and central neurons. In patients with multiple sclerosis, BDNF expression is often decreased and believed to reflect ineffective repair mechanisms. s a reliminary exploration, we examined the production of BDNF on the part of peripheral blood mononuclear cells in three groups: patients with Chronic Fatigue Syndrome (CFS [n=15]), patients with multiple sclerosis n=57), and a set of putatively healthy controls (n=37).
Methods: Mononuclear cells were extracted from peripheral blood samples and cultured for 48 hours. Production of BDNF was eval.. View More»
