Leonard Jason
Tanzania
Research Article
Brain Derived Neurotrophic Factor is Decreased in Chronic Fatigue Syndrome and Multiple Sclerosis
Author(s): Matthew Sorenson, Leonard Jason, Jonna Peterson, Joshua Herrington and Herbert MathewsMatthew Sorenson, Leonard Jason, Jonna Peterson, Joshua Herrington and Herbert Mathews
Objective:
This study examined the levels of a major regulator of neuronal survival, brain derived neurotrophic factor (BDNF) in two populations: individuals with multiple sclerosis and chronic fatigue syndrome. BDNF is a protein involved in the maintenance and maturation of both peripheral and central neurons. In patients with multiple sclerosis, BDNF expression is often decreased and believed to reflect ineffective repair mechanisms. s a reliminary exploration, we examined the production of BDNF on the part of peripheral blood mononuclear cells in three groups: patients with Chronic Fatigue Syndrome (CFS [n=15]), patients with multiple sclerosis n=57), and a set of putatively healthy controls (n=37).
Methods: Mononuclear cells were extracted from peripheral blood samples and cultured for 48 hours. Production of BDNF was eval.. View More»
