Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Lundsgaard E
Skolemarken 32, Broballe, 6430 Nordborg,
Denmark
Review Article
Etiology of Multiple Sclerosis
Author(s): Lundsgaard ELundsgaard E
Multiple Sclerosis (MS) is characterized by degradation of the essential myelin sheath around the nerves in the white matter of the central nervous system (CNS). I argue that this is caused by insufficient production of myelin, as myelin-forming oligodendrocytes become damaged by excess steroid receptors type 1 in the cytoplasm, which clump and release zinc due to the relative lack of their ligands. This may gradually lead to hyperphosphorylation of tau protein. Accordingly, the etiological basis for MS is thought to be at least three synergistic systems with the components, steroid receptors type 1 and their ligands: vitamin D, estrogen and testosterone. To prove this hypothesis with its many variables, it has been necessary to use a system of non-homogeneous differential equations.
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