Etiology of Multiple Sclerosis | 47093

Journal of Multiple Sclerosis

ISSN - 2376-0389
NLM - 101654564


Etiology of Multiple Sclerosis

Lundsgaard E

Multiple Sclerosis (MS) is characterized by degradation of the essential myelin sheath around the nerves in the white matter of the central nervous system (CNS). I argue that this is caused by insufficient production of myelin, as myelin-forming oligodendrocytes become damaged by excess steroid receptors type 1 in the cytoplasm, which clump and release zinc due to the relative lack of their ligands. This may gradually lead to hyperphosphorylation of tau protein. Accordingly, the etiological basis for MS is thought to be at least three synergistic systems with the components, steroid receptors type 1 and their ligands: vitamin D, estrogen and testosterone. To prove this hypothesis with its many variables, it has been necessary to use a system of non-homogeneous differential equations.