Antiphosphatidylethanolamine Antibodies: New Pieces to the Puzzle of the Antiphospholipid Syndrome?
Author(s): Caroline Zaratzian, Joris Zypinoglou, Pierre Emmanuel Morange and Nathalie BardinCaroline Zaratzian, Joris Zypinoglou, Pierre Emmanuel Morange and Nathalie Bardin
Objective: To show the contribution of antiphosphatidylethanolamine antibodies (aPE) screening in Antiphospholipid antibody syndrome (APS) diagnosis, especially in Antiphosphopholipid Syndrome (SNAPS) patients, based on litterature data. Methods: A comprehensive literature review of English-language articles from January 1st 2000 to December 31th 2014 was performed using PudMed. Keywords used for the search were: seronegative antiphospholipid antibody OR phosphatidylethanolamine function, biosynthesis and physiological roles OR antiphosphatidylethanolamine antibody OR seronegative antiphospholipid syndrome. Results: Although aPE was not included in the Sapporo criteria for the classification of APS, many studies described a significant association between aPE and the main clinical events of AP.. View More»