Can Vitamin D Slow Progression of Osteoarthritis?
Author(s): Vishal Chand, Jaya Prakash, Md. Tashfeen Ashraf and Varsha GuptaVishal Chand, Jaya Prakash, Md. Tashfeen Ashraf and Varsha Gupta
Osteoarthritis (OA) is a chronic and prevalent joint disease resulting in degenerative changes in the cartilage. Now-a-days vitamin-D is emerging as an important component which has a wide biological effects. The studies are evaluating the beneficial effects of vitamin-D in osteoarthritis therefore the present investigation was planned to analyze i) levels of vitamin-D in selected controls and OA patients, ii) monitor gene expression changes in CYP2R1, CYP3A4, CYP27B1, CYP24A1 and CYP27A1, whose products are involved in vitamin D metabolism. Our result shows that there was no significant difference in the vitamin-D levels in OA versus controls. The mean vitamin D levels in controls was 35.9 ng/ml (3 had ViD<20g/ml) and in OA patients was 35.66 ng/ml (3 had Vit D<20ng/ml). However gene expression of CYP2R1, CYP3A4 was reduced CYP24A1, CYP27B1 showed no variation in expression and.. View More»