Hossein Mirmiranpour
Vali-Asr Hospital, School of Medicine,
Tehran
West Indies
Research Article
Effect of Memantine on Oxidative and Antioxidant Indexes Among Elderly Patients with Prediabetes and Mild Cognitive Impairment
Author(s): Raheleh Alimoradzadeh, Hossein Mirmiranpour, Payam Hashemi, Shaghayegh Pezeshki and Salome Sadat SalehiRaheleh Alimoradzadeh, Hossein Mirmiranpour, Payam Hashemi, Shaghayegh Pezeshki and Salome Sadat Salehi
Objective: Mild cognitive impairment (MCI) is a cognitive syndrome in the elderly individuals. MCI drug treatment is still under debate. On the other hand, MCI progress is higher in people with diabetes mellitus type 2. This study was designed to determine the effect of Memantine on oxidant and antioxidant indexes among the elderly with prediabetes and MCI.
Method: The present study is a double-blind randomized clinical trial which was conducted on 50 elderly patients over 60 years of age who had been diagnosed with prediabetes and MCI. Subjects were divided into intervention and control groups. The intervention group was treated with Memantine and Metformin and the control group received Metformin only. The data were collected before and after the study by blood tests and clinical examination and analyzed by using correlation test, independen.. View More»
