Raheleh Alimoradzadeh, Hossein Mirmiranpour, Payam Hashemi, Shaghayegh Pezeshki and Salome Sadat Salehi
Objective: Mild cognitive impairment (MCI) is a cognitive syndrome in the elderly individuals. MCI drug treatment is still under debate. On the other hand, MCI progress is higher in people with diabetes mellitus type 2. This study was designed to determine the effect of Memantine on oxidant and antioxidant indexes among the elderly with prediabetes and MCI.
Method: The present study is a double-blind randomized clinical trial which was conducted on 50 elderly patients over 60 years of age who had been diagnosed with prediabetes and MCI. Subjects were divided into intervention and control groups. The intervention group was treated with Memantine and Metformin and the control group received Metformin only. The data were collected before and after the study by blood tests and clinical examination and analyzed by using correlation test, independent and paired sample t-test in SPSS v.23 software.
Results: The subjects included 22 men and 28 women. The mean age subject was 72.87 ± 3.95. Regarding the control group, the oxidative indexes including Advanced Glycation End Products (AGEs) and Advanced oxidation protein products (AOPP) decreased significantly (p value<0.001, df: 48). Regarding the intervention group, the oxidant indexes including AGEs and AOPP significantly decreased. In addition, antioxidant indexes such as LAP and Lecithin-cholesterol acyltransferase (LCAT) indexes increased considerably (p value<0.001, df: 48).
Conclusion: Based on the results, the combination therapy with Memantine and Metformin for elderly patients with Prediabetic State and MCI may decrease oxidant indexes and increase the effect on antioxidant indices.