Gisele Zapata-Sudo
Centro de Ciencias da Saude, Instituto de Ciencias Biomedicas,
Bloco J, Sala 14, Rio de Janeiro, RJ, 21941-590
Brazil
Research Article
Targeting of the Adenosine Receptors as A Novel Strategy for the Treatment of Arterial Hypertension
Author(s): Gisele Zapata-Sudo, Susumu Z Sudo, Allan K.N. Alencar and Roberto T SudoGisele Zapata-Sudo, Susumu Z Sudo, Allan K.N. Alencar and Roberto T Sudo
Objective: The effects of loud noise (80 dB) on neurogenesis in the sub-ventricular zone (SVZ) and the
hippocampal sub-granular zone (SGZ) was investigated in vivo in the rat brain using positron emission tomography
(PET) with 3’-deoxy-3’- [18F]fluoro-L-thymidine ( [18F]FLT), a marker for thymidine kinase I (TK-1) related to cell
proliferation and for neurogenesis in SVZ and SGZ.
Methods: Five young Sprague-Dawley rats were exposed to loud noise from two speakers set in front of their
cages during the night for 4 nights, and 5 control rats were exposed to normal quiet conditions. PET was performed
4 days after the exposure.
Results: The accumulation of [18F] FLT in SVZ was significantly lower in the rats with noise exposure than in the
control rats. The level of [18F] FLT uptake was lower in the SVZ than in the SGZ... View More»
