David Cullis-Hill
Australia
Commentary
Pentosan Polysulfate as a Disease Modifier of Cartilage Degeneration in Experimental Osteoarthritis
Author(s): Ahmed M Elmesiry, Magdi A Seleim, Ali A Mansour and David Cullis-HillAhmed M Elmesiry, Magdi A Seleim, Ali A Mansour and David Cullis-Hill
Reasons for performing study: Disease modifying drugs for Osteoarthritis (OA) is an important trend of development of an appropriate therapeutic protocol for both human and animal. To date no ideal OA treatment protocol has been described. Objectives: To assess clinical, histologic, and biochemical effects of sodium pentosan polysulfate (NaPPS) administered intramuscullary (IM) for treatment of experimentally induced osteoarthritis in donkeys. Study design: OA was induced using repeated injection of allogenous donkey cartilage. Six donkeys received NaPPS (3 mg/kg, IM) on study days 70, 77, 84, and 91. Six control donkeys received the same volume of saline (0.9% w/v NaCl) IM on study days 70, 77, 84, and 91. Clinical, gross, histologic, histochemical, and biochemical findings as well as synovial fluid analysis were evaluated. Methods of testing hypotheses: Lameness score, carpal circum.. View More»
