Cannabis is one of the most widely used and commercialized illegal drugs worldwide, notably amid young adults. The neuro-biological mechanisms of cannabis, particularly in adolescents, have yet to be identified. The purpose of this study was to evaluate a cohort of 73 cannabis users (ages 22-36, 19 females) and his 73 healthy controls (ages 22-36, females). We observed some momentous differences in local structural/functional network measures (such as grade along with clustering coefficient), extended in the insular and anterior cranial cortices, and in the lateral/medial temporal cortex .An abundant structural network of clubs showed a normal tendency to distribute in the bilateral frontal, temporal, and occipital regions. The superior and inferior temporal gyri of the two groups did, however, show a few minor variations. Functionally rich clavate nodes were located primarily in the parietal and posterior regions,with minor differences between the groups that were found primarily in the centrotemporal and parietal regions. In multiple regions, regional network metrics of structural/functional networks have been linked to Time of Cannabis Use (TUC). However, no differences between cannabis users and healthy control of global network measures were discovered, and there was no association with cannabis use in structural/functional networks, which demonstrated small-world ownership in both groups. With the exception of the link between termination within the subicule area and TUC, all significant associations between network measures and TUC were determined to be non-significant after FDR adjustment. In conclusion, our findings showed that local topological characteristics of structural and functional networks were altered in cannabis users, but overall brain network structure was unaltered.
