Dental Phenotypes in Van der Woude Syndrome: An Integrative | 44325

Journal of Health and Medical Research


Dental Phenotypes in Van der Woude Syndrome: An Integrative Review

Aline Cris tina da Silva Trevizan, Pollyana Pereira Teotonio dos Santos, Maria Carolina de Moraes Pereira and Lucimara Teixeira das Neves*

Introduction: Van der Woude Syndrome (VWS) consists of a genetic abnormality attributed to mutations in the IRF6 gene, characterized by the presence of paramedian pits in the lower lip, cleft lip and/or palate and hypodontia. Phenotypes of the syndrome are related to the oral cavity, and then other dental anomalies would also be present in this specific syndrome.

Objective: The aim of this study was to identify different dental phenotypes in subjects with VWS through an integrative review of the literature.

Materials and methods: A systematic search was conducted in Pubmed/Medline for articles which assessed dental phenotypes in van der Woude syndrome.

Results: Six publications were selected, considering the eligibility criteria of the articles. Different dental phenotypes are described in this syndrome. Tooth agenesis is the most common phenotype and is already associated as one of the characteristics of the syndrome. However, taurodontism has also been reported with a prevalence of 46% in these patients.

Conclusion: It is important to understand the nature and extent of the dental phenotype variation in VWS patients, allowing an adequate approach to oral rehabilitation planning for these patients.