International Human Toponome Project, ToposNomos Ltd. Germany
Keynote: J Neurol Neurophysiol
Molecular Unlimited Systems-Imaging Cycler (IC®) robotics, a toponome imaging system, decodes the hitherto unknown and
unexpected dark space of diseases at >4.5x10 to the 481 combinatorial molecular resolution in situ/in vivo. As shown for
ALS, the dark space is not a nihility or nothingness, but an almost continuous ontological contexture, a quasi-infinite parallelism
of polyphony, which can be translated into efficient therapies, and in clinical condensed matter physics of ALS. An ALS patient
was treated on this basis by depletion therapy of axotomy - competent cells (ACC) detected by an IC robot resulting in durable
recovery. All tested ALS patients display these cells in their blood. The introduced approach is likely to be an efficient new therapeutic
approach based on hypothesis-free methods of ALS-systems analysis on a large scale in topologically intact tissue structures, as
required for approaches to condensed matter physics of living matter.
1. Schubert W, Bonnekoh B, Pommer A J, Philipsen L, Boeckelmann R, Maliykh J, Gollnick H, Friedenberger M, Bode M and Dress A W (2006) Analyzing proteome topology and function by automated multidimensional fluorescence microscopy. Nat Biotechnol 24:1270-1278.
2. Friedenberger M, Bode M, Krusche A and Schubert W (2007) Fluorescence detection of protein clusters in individual cells and tissue sections by using toponome imaging system: sample preparation and measuring procedures. Nat Protoc. 2(9):2285-94.
3. Hillert R, Gieseler A, Krusche A, Humme D, Rowert-Huber H J, Sterry W, Walden P and Schubert W (2016) Large molecular systems landscape uncovers T cell trapping in human skin cancer. Sci Rep. 6:19012.
4. Schubert W (2015) Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis. Cytometry A 87(8):696-703.
5. Schubert W (2018) A platform for parameter unlimited molecular geometry imaging obviously enabling life saving measures in ALS. Advances in Pure Mathematics 8(3).
Walter Schubert is Director of the International Human Toponome Project, Munich, Germany. Based on observations on the island of KOS, Greece, in 1987 he formulated the sun light hypothesis, and derived Imaging cycler robotics for simultaneous imaging of millions of molecular signals in one and the same sample, e.g. in diseased tissues of ALS: the technology applying millions of quasi channels to reveal the toponome. He is an Emeritus Professor for toponomics of the International Faculty, CASMPI Partner Institute for Computational Biology, Shanghai, China, and HD in Germany. He has received many national and international awards, honors and has 150 publications, and holds many technology and therapy patents.