Muktader A Kalbi, Simeon M Marasigan, Joseree Ann S Catindig and Jose C Navarro
Accepted Abstracts: J Neurol Neurophysiol
Objective:The purpose of this study was to investigate and compare the cerebral hemodynamic status (blood flow velocity and pulsatility index) of cognitively impaired and non-cognitively impaired elderly using Transcranial Doppler (TCD). Specifically, it aimed to determine if TCD can be a biomarker for patients with cognitive impairment. Methods: This is a cross sectional study conducted in Jose R. Reyes Memorial Medical Center (JRRMMC) Neurology OPD. Forty patients were selected using convenience sampling and were screened using the Montreal Cognitive Assessment-Philippines (MoCA-P). Scores ≥21 were grouped under non-cognitively impaired elderly while scores <21 were under cognitively impaired elderly. Transcranial ultrasound basal examination were performed using a 2-MHz power motion probe (M-mode) to study the middle cerebral artery (MCA), the anterior circulation artery (ACA) and posterior cerebral artery (PCA). Results: Our findings showed that patients with cognitive impairment have lower mean flow velocity (MFV) (p value=0.0001) and higher pulsatility index (PI) (p value=0.0001) when compared to non-cognitively impaired elderly. Reduction in MFV and increase in PI in the cognitively impaired group may be related to microvessel damage brought about by hypertension, diabetes mellitus and smoking. Conclusion: Cognitively impaired elderly has significantly higher PI and lower MFV compared to normal elderly. TCD can be a biomarker for screening patients with cognitive impairment.