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Protection against oral mucositis in patients undergoing radiothe | 49108

Oncology & Cancer Case Reports

ISSN - 2471-8556

Protection against oral mucositis in patients undergoing radiotherapy of the head and neck with topical mucoadhesive gel containing Propolis

15th World Congress on CANCER THERAPY, BIOMARKERS & CLINICAL RESEARCH

December 05-07, 2016 Philadelphia, USA

Vagner Rodrigues Santos, Vladimir R.A.S. Noronha, Henrique C. Meira, Ruan S. Silva, Mariana T. Rodrigues, Luis Guilherme V. Madeira, Mayara F. Paiva and Barbara F. G. Queiroz

Universidade Federal de Minas Gerais, Brazil

Posters & Accepted Abstracts: Oncol Cancer Case Rep

Abstract :

The objective of this phase II study was to determine the effectiveness of a mucoadhesive propolis gel in the prevention of radiation-induced oral mucositis. Thirty-four patients who were selected to undergo radiation therapy for oral cancer were included in this open-label trial. They were advised to use a mucoadhesive gel containing propolis 5,0% w/v three times a day starting one day before the course of radiation therapy and concluding after 2 weeks of radiation therapy. A weekly follow-up for evaluation of food intake, pain and grading of mucositis was performed. In order to confirm the absence of Candida-related mucositis in patients who developed mucositis, it was performed exfoliative cytology of buccal mucosa, palate and tongue and the material for Candifast(?®) Candida species identification. At the end of the study was made the compliance of patients, quality, appreciation and acceptance of product evaluation. Twenty patients did not develop mucositis, two patients developed grade 1 mucositis and two patients developed grade 2 mucositis. None of the patients discontinued food intake and no pain was observed during the study. Candidosis was not detected in any patient. Mucoadhesive propolis gel could be considered as a potential topical medication for preventing radiation-induced oral mucositis. Acnowledgements:FAPEMIG/CNPq/ CENEXFOUFMG/ PROEX-UFMG.

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