Pechersky AV and Semiglazov VF
North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia N.N. Petrov National Medicine Research Center of oncology, St. Petersburg, Russia
Scientific Tracks Abstracts: Oncol Cancer Case Rep
Germinative mutations determine hereditary predisposition to various diseases, initiating their early manifestation and rapid progression. At the same time, the proportion of germinative mutations is significantly less compared to the somatic mutations prevailing in humans that occur in various cells throughout their life (during ontogenesis). The appearance of malignant tumors, type 2 diabetes, hypercholesterolemia and other diseases / pathological conditions in aging people is accompanied by the development of corresponding somatic mutations. Somatic mutations provide genetic fixation of compensatory-adaptive reactions (functional at the initial stage) developing in aging people in response to impaired tissue renewal / regeneration, decreased production of sex hormones and other pathological conditions. The mechanism of somatic mutations is similar to the genetic changes occurring in cells during their differentiation and is due to the ranking of genes with the removal of non-functioning DNA sections. This is associated with irreversible changes in malignant and other cells (for example, those that have become insulin-resistant). Timely restoration of tissue renewal (regeneration) and adequate replacement of sex hormones in aging people can significantly reduce the risk of developing compensatory adaptive responses and accordingly, subsequent somatic mutations that cause irreversible cellular changes.
1. AV, Pechersky VI, Aseev MV, Droblenkov AV, Semiglazov VF. Several aspects of the regeneration process carried out by means of pluripotent stem cells. Tsitologiya 2008; 50(6): 511-520 (submitted July 06, 2007).
2. Pechersky AV, Pechersky VI, Smolyaninov AB, Vilyaninov VN, Adylov ShF, Shmelev AYu, Pecherskaya OV, Semiglazov VF. Regeneration and carcinogenesis. Journal of Stem Cells 2015; 10(4): 255-270.
3. Pechersky AV, Pechersky VI, Vilyaninov VN, Pecherskaya OV, Semiglazov VF. Regeneration’s role in the development of desensitization and immunological tolerance. Journal of Stem Cells 2019; 14(2): 75-102 (submitted July 19, 2019).
4. Pechersky AV. The influence of partial androgen deficiency in aging men (PADAM) on the development of benign prostatic hyperplasia and prostate cancer. American Research Journal of Urology 2019; 3(1): 1-16.
5. Pechersky AV. Role of partial androgen deficiency of aging men in development of the metabolic syndrome. American Research Journal of Urology 2016; 1: 1-13.
Pechersky AV is an Associate Professor at North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia. His achievements include the original articles devoted to the influence of partial androgen deficiency among aging men (PADAM) on the development of benign prostatic hyperplasia, prostate cancer and metabolic syndrome, diagnostics and treatment of partial androgen deficiency of aging men, regeneration, immune system, carcinogenesis, cicatrization, desensitization, immunological tolerance and antitumor immunotherapy.