Alina K Piekarek
Wrocław University Hospital, Poland
Scientific Tracks Abstracts: J Neurol Neurophysiol
This review discusses the glaucomatous degeneration of the brain and the optic pathways detected in MR Imaging. Glaucoma is a heterogeneous condition causes gradual vision loss associated with the optic pathways damage. The neuropathological mechanisms are not clear. By assessment of the brain using high-resolution techniques of magnetic resonance imaging, detailed structural and functional changes can be detected in glaucoma patients. MRI enables the entire visual pathway evaluation, from the optic nerves to the occipital cortex. Tractography based on diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) can be used for discriminating optic pathway fibers. Diffusion parameters from voxels along of the visual pathway allow for quantitative evaluation of the white matter disintegration. The problem of the crossing fibers, acquisition time, multiparametric analysis, pre-chiasmatic and postchiasmatic fibers and the spatial resolution artifacts will be discussed by showing examples from my running researches. High-resolution 3D volumetric MR sequences provide the information of cortical glaucomatous reduction, which can be calculated from Brodmann‚??s areas of the visual cortex. The occipital cortex activity is detected using functional MRI (fMRI) techniques by monocular or binocular stimulation. The certain aspects of fMRI and voxel-based volumetry will be elaborated. The neuro-ophthalmological entities, which can mimic glaucoma will be reviewed and considered based on cases from my Department. Magnetic resonance imaging (MRI) characterizes the glaucomatous neuropathy by detecting the brain changes along the optic pathways.
Alina K Piekarek has completed her PhD from University of Medical Sciences in Poznań /Poland/ and afterward fellowship at Vienna Medical University /Austria/ in Department of Biomedical Imaging and Image-guided Therapy. She is European Board Head and Neck Radiologist and leads researches in the neuroophthalmology at Wrocław University Hospital Poland.
E-mail: [email protected]