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Median nerve modulation markedly diminishes ventricular arrhythmi | 48711

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Median nerve modulation markedly diminishes ventricular arrhythmias after myocardial infarction in rabbits

7th Global Neurologists Annual Meeting on Neuro Surgery and Interventional Radiology

August 22-24, 2016 Vienna, Austria

Zhengqin Zhai

Peking Union Medical College, China

Scientific Tracks Abstracts: J Neurol Neurophysiol

Abstract :

Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the occurrence of ventricular arrhythmias after myocardial infarction. Here, we hypothesize that a novel pathway nerve stimulation - median nerve stimulation inhibit the occurrence of ventricular arrhythmias after myocardial infarction in rabbits. Two weeks after the ligation of the left coronary artery, 11 surviving New Zealand rabbits were randomized to median nerve stimulated (MI-MNS, n = 5) group and sham-stimulated (MI-SS, n = 6) group. Using an implantable electrical stimulator, we stimulated the bilateral median nerve for 2 weeks with the frequency of 5 HZ, width of 200ms, cycle of 10s on and 30s off, and the intensity of electrical stimulation was adjusted to the threshold of not resulting in the tremble of upper limbs. A holter was implanted to record the types and frequencies of arrhythmias. The treated rabbits had significantly lower percentage of ventricular arrhythmias (3.67% ├?┬▒ 1.73% vs. 6.69% ├?┬▒ 2.50%, p < 0.001) and lower norepinephrine (NE) level in blood (7.88 ├?┬▒ 2.34 pg/ml vs. 17.57 pg/ml├?┬▒ 11.72pg/ml, p = 0.01) than the untreated rabbits. Median nerve modulation markedly decreased the incidence of ventricular arrhythmias after myocardial infarction in rabbits through reducing the NE level in blood.

Biography :

Zhengqin Zhai has completed her Bachelor’s degree from Shandong University and now has been working for her Master’s degree in Peking Union Medical College.

Email: Zhengqin712@outlook.com

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