IL-33 stimulation down-regulated ADAMTS15 gene and protein in U11 | 49502

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

IL-33 stimulation down-regulated ADAMTS15 gene and protein in U118 glioblastoma cell

14th World Congress on Neurology and Neurological Disorders

July 17-18, 2017 Chicago, USA

Nezihe Asli Bayram

Suleyman Demirel University, Turkey

Posters & Accepted Abstracts: J Neurol Neurophysiol

Abstract :

ADAMTS (A disintegrin-like and metalloproteinase domain with thrompospondin-1 repeats) are a large family of proteoglycanase that show proteolytic activity towards proteoglycans like aggrecan, brevican, neurocan and versican. Interleukin-33 (IL-33) is an IL-1 cytokine family member that uniquely play a role as a cytokine and nuclear factor. It is released by necrotic epithelial cells and activated innate immune cells as an alarming danger signal. ADAMTS and IL-33 implicated in brain cancer pathogenesis. We aimed to seek the amount of ADAMTS15 in U118 glioblastoma cell line which was stimulated by IL-33. Western blot and Real-time PCR methods were used. IL-33 treatment decreased ADAMTS15 protein and mRNA amount significantly. Therefore, ADAMTS15 potentially has a role in glioblastoma pathobiology.

Biography :