Hippocampal MAP2 levels reduce in the experimental sub-arachnoid | 49034

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Hippocampal MAP2 levels reduce in the experimental sub-arachnoid hemorrhage: A preliminary study

2nd International Conference on Central Nervous System Disorders & Therapeutics

December 05-07, 2016 Dubai, UAE

Didem T Cosan, Fulya Buge Ergen, Turhan Kandemir and T Erhan Cosan

Eski├?┬?ehir Osmangazi University, Turkey

Posters & Accepted Abstracts: J Neurol Neurophysiol

Abstract :

Objective: Subarachnoid hemorrhage is associated with severe morbidity and mortality. Disease may lead to impaired consciousness and cognitive functions. Neuronal processing is supported by intracellular microtubule integrity and functions. MAP2 interacting with microtubules leads to stabilization of microtubules, inhibition of depolymerization and increase in microtubule rigidity. Material & Method: We investigated hippocampal tissue microtubule-associated protein 2 (MAP2) levels in the rat groups housing in isolated, standard or enriched environment, and results were obtained at 7th and 14th days after experimental subarachnoid hemorrhage. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the MAP2 levels in rat├ó┬?┬?s hippocampal tissue samples. This assay was performed using commercially available ELISA kit. Results: Hippocampal MAP2 levels were reduced in all groups at first and second week after subarachnoid hemorrhage. Nevertheless, reduced MAP2 levels are more elevated in the rats housing in enriched environment compared with other groups. Conclusion: In the progression of experimental subarachnoid hemorrhage, hippocampal MAP2 levels are being reduced despite changing environmental status. Besides, the enriched environment in the subarachnoid hemorrhage may need further investigations.

Biography :

Didem T Cosan is currently working as an Assistant Professor in the Department of Medical Biology at Eskisehir Osmangazi University (Eskisehir, Turkey). He has published several original research papers in reputed journals and also participated in several scientific meetings.