Emerging role of brain fractalkine signaling in the behavioral an | 49008

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Emerging role of brain fractalkine signaling in the behavioral and biochemical disturbances in the course of depression

2nd International Conference on Central Nervous System Disorders & Therapeutics

December 05-07, 2016 Dubai, UAE

Budziszewska Bogus??awa, Basta Kaim Agnieszka, Slusarczyk Joanna and Chamera Katarzyna

Polish Academy of Sciences, Poland

Posters & Accepted Abstracts: J Neurol Neurophysiol

Abstract :

Current data reveals that early adverse life experiences may affect the developmental processes of the brain and can be involved in the pathogenesis of many psychiatric disorders including depression. It has been highlighted that stress during pregnancy activates the immune response in the offspringâ??s central nervous system. Results also show important role fractalkine (CX3CL1) in the neuron-microglia interactions and consequently in production of pro- and anti-inflammatory factors in the brain. Therefore, the aim of our study was to examine the impact of prenatal stress as well as the role of fractalkine (CX3CL1) on the behavioral and biochemical changes in adult rats. Adult 3-months old rats offspring (control and prenatally stressed), after behavioral verification, received icv injections with exogenous fractalkine. After the treatment, we evaluated time-dependent effects of fractalkine administration on the behavioral parameters. Moreover, we measured the changes in the production of pro-inflammatory cytokines in the two structures: Hippocampus and frontal cortex. The obtained data show that 7 days after treatment with fractalkine the behavioral disturbances evoked by prenatal stress procedure were normalized. Moreover, prenatal stress activates production of pro-inflammatory cytokines in the hippocampus and frontal cortex. Interestingly, treatment with fractalkine inhibited the expression of these factors mainly in the frontal cortex. Summing up, our study shows that the changes in fractalkine may play an important role in the pathogenesis of depression. Importantly, the action of the chemokine is connected with its effect on production of inflammatory factors in the brain.

Biography :

Budziszewska Bogus??awa has completed her PhD in 1981 at the Institute of Pharmacology, Polish Academy of Sciences in Cracow, Poland. Since 2004, she is Head of Immunoendocrinology Laboratory in the Institute of Pharmacology; since 2011, a Professor of Medical Sciences and from 2011 Head of Department of Biochemical Toxicology, Jagiellonian University, Medical College, Cracow, Poland. She has published more than 100 papers in reputed journals.