Elevated hippocampal tau levels at the early stage in experimenta | 49032

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Elevated hippocampal tau levels at the early stage in experimental subarachnoid hemorrhage

2nd International Conference on Central Nervous System Disorders & Therapeutics

December 05-07, 2016 Dubai, UAE

T Erhan Cosan, Turhan Kandemir, Fulya Buge Ergen and Didem T Cosan

Eski√?¬?ehir Osmangazi University, Turkey

Posters & Accepted Abstracts: J Neurol Neurophysiol

Abstract :

Objective: Subarachnoid hemorrhage is a devastating disease with up to 95% of survivors reporting cognitive impairment and poor quality of life. Microtubule integrity and thus its role on the neuronal polarity are important in conserving cytoskeletal structure and function. Tau is well known protein interacting with mostly axonal microtubules. They support the stabilization of microtubules, inhibition of depolymerization and microtubule rigidity. In our study, we investigated hippocampal tau protein tissue levels in the rats housed in isolated, standard and enriched environment after experimental subarachnoid hemorrhage. Material & Method: Hippocampal microtubule-associated protein tau (MAPT) levels were determined by enzyme-linked immunosorbent assay (ELISA) kit (Elabscience) according to the manufacturer√ʬ?¬?s instructions. Results were obtained at 7th day and 14th day after subaracnoid hemorrhage. Results: At first week after subarachnoid hemorrhage, tau levels were increased in the rats housed in isolated and standard environment, reduced in the rats housed in enriched environment. Two weeks after subarachnoid hemorrhage, tau levels reduced in all groups. Conclusion: At the early stage of subarachnoid hemorrhage in the experimental rats, axonal tau proteins to stabilize neuronal microtubule integrity with standard and isolated environment housing may be more favorable.

Biography :

T Erhan Cosan is currently working as a Professor in the Department of Neurosurgery at Eskisehir Osmangazi University (Eskisehir, Turkey). He has published several original research papers in reputed journals and also participated in several scientific meetings.