Effects on flavonoids with lipid-modulating properties on ApoE4-i | 47931

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Effects on flavonoids with lipid-modulating properties on ApoE4-induced Aß production

International Conference on Central Nervous System - Drug Effects & Novel Drug Development

September 5-7, 2012 DoubleTree by Hilton Philadelphia Center City, USA

Kenza E. Benzeroual

Scientific Tracks Abstracts: J Neurol Neurophysiol

Abstract :

Alzheimer?s diseaseis characterized by deposition of insoluble protein aggregates of amyloid beta (Aβ). Amyloid precursor protein (APP) is the central protein involved in AD pathology as it serves as the precursor for Aβ generation. The initial trigger of the disease is largely unknown, but several studies reported that the apolipoprotein (apo) E4 is a major risk factor for AD. Others have suggested that ApoE4 has isoform-specific effects on the deposition or clearance of Aβ peptides. Thus, investigating new ways to slow or reverse the neurodegenerative pathways involved, will guide new strategies for drug development. The present in-vitro studies,investigated the effects of cholesterol modulating agents and flavonoidson ApoE4- induced APP processing into Aβ peptides in neuronalcells stably transfected with human wild-type APP695.Our present data support a therapeutic potential for these agents in inhibitngApoE4-induced Aβ production

Biography :

Kenza Benzeroual has completed her PhD at the University of Montreal, Montreal, Canada, and a postdoctoral fellowship from Columbia University and the New York Psychiatric Institute. Dr. Benzeroualis a faculty at the Arnold and Marie Schwartz College of Pharmacy-Long Island University, Brooklyn, NY,teaching Pharmacology and Pharmacogenomics to the PharmD and Graduate Students, as well as pursuing research in the area of neurodegeneration.