Jun Liang Yuan
Beijing Chaoyang Hospital - Capital Medical University, China
Posters & Accepted Abstracts: J Neurol Neurophysiol
Background: We aimed to explore the relation between the microstructural integrity of white matter using the technique of diffusion tensor imaging (DTI) and changes of cognition in leukoaraiosis (LA). Methods: Fifty patients with LA and 50 age- and gender-matched controls were recruited consecutively. The average values of mean diffusivity (MD) and fractional anisotropy (FA) were quantified both within white matter lesions (WMLs) and normalappearing white matter (NAWM) from the regions of interest (ROIs). Results: We found significantly decreased FA and increased MD in WMLs at the 5 ROIs than that in NAWM and controls (p<0.05). The values of FA in NAWM were significantly lower at centrum semiovale and posterior periventricular white matter than those of controls (p<0.05). The values of MD in NAWM were significantly higher at the anterior periventricular white matter and corpus callosum than those of controls (p<0.05). The values of FA in NAWM located at anterior periventricular white matter correlated inversely with the Z scores of executive function (r=-0.420, p=0.028). Conclusions: DTI may provide some important information about the cognitive dysfunction in patients with LA, which may largely attribute to the disconnection of cortico-subcortical pathways, with the evidence of reduced FA and increased MD.